ChemInform Abstract: Enantio- and Diastereoselective Synthesis of γ-Amino Alcohols

Ir‐catalyzed asymmetric transfer hydrogenation of β‐amino ketones leads to the corresponding N‐protected anti‐γ‐amino alcohols, while Rh‐catalyzed asymmetric hydrogenation affords the syn‐products.

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Bibliographic Details
Published inChemInform Vol. 47; no. 3; p. no
Main Authors Verkade, Jorge M. M., Quaedflieg, Peter J. L. M., Verzijl, Gerard K. M., Lefort, Laurent, van Delft, Floris L., de Vries, Johannes G., Rutjes, Floris P. J. T.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 29.12.2015
WILEY‐VCH Verlag
Subjects
amino alcohols (acyclic compounds)
catalysis
catalysis, phase‐transfer catalysis
diastereoselective syntheses
diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism)
enantioselective syntheses (incl. cis/trans-isomerism)
hydrogenation
phase-transfer catalysis
reduction
reduction, hydrogenation
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Summary:Ir‐catalyzed asymmetric transfer hydrogenation of β‐amino ketones leads to the corresponding N‐protected anti‐γ‐amino alcohols, while Rh‐catalyzed asymmetric hydrogenation affords the syn‐products.
Bibliography:istex:8FADC51980762B9859BCFD70D0E4B67B310BC5AF
ark:/67375/WNG-F286JJN8-3
ArticleID:CHIN201603052
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201603052