ChemInform Abstract: Lewis Acid Activated Synthesis of Highly Substituted Cyclopentanes by the N-Heterocyclic Carbene Catalyzed Addition of Homoenolate Equivalents to Unsaturated Ketoesters

The use of Ti(O‐Pr)4 as a mild Lewis acid in combination with NHC catalysis is essential for the activation of α,β‐unsaturated aldehydes and promotion of the conjugate addition to ketoesters.

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Bibliographic Details
Published inChemInform Vol. 42; no. 24; p. no
Main Authors Cohen, Daniel T., Cardinal-David, Benoit, Scheidt, Karl A.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 14.06.2011
WILEY‐VCH Verlag
Subjects
cyclopentane derivatives
diastereoselective syntheses
diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism)
enantioselective syntheses (incl. cis/trans-isomerism)
ring closure reactions
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Summary:The use of Ti(O‐Pr)4 as a mild Lewis acid in combination with NHC catalysis is essential for the activation of α,β‐unsaturated aldehydes and promotion of the conjugate addition to ketoesters.
Bibliography:istex:62277B54DA97AB238D5B95B5DB3D2922128C60AA
ArticleID:CHIN201124062
ark:/67375/WNG-2PMTS30W-9
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201124062