Correlation between molecular and clinical events in the evolution of chronic myelocytic leukemia to blast crisis

A patient with typical Philadelphia chromosome (Ph1)-positive chronic myelocytic leukemia (CML) was studied during sequential phases of disease: (1) initial chronic phase; (2) myeloid blast crisis; (3) second chronic phase; and (4) accelerated disease. A point mutation in the coding sequence of the...

Full description

Saved in:
Bibliographic Details
Published inBlood Vol. 77; no. 11; pp. 2441 - 2444
Main Authors Foti, A, Ahuja, HG, Allen, SL, Koduru, P, Schuster, MW, Schulman, P, Bar-Eli, M, Cline, MJ
Format Journal Article
LanguageEnglish
Published 01.06.1991
Online AccessGet full text

Cover

More Information
Summary:A patient with typical Philadelphia chromosome (Ph1)-positive chronic myelocytic leukemia (CML) was studied during sequential phases of disease: (1) initial chronic phase; (2) myeloid blast crisis; (3) second chronic phase; and (4) accelerated disease. A point mutation in the coding sequence of the p53 gene first appeared concomitantly with the blast crisis and then disappeared with the re-establishment of a second chronic phase. The chromosomal concomitant of the molecular alteration was a deletion of 17p. These observations suggest that abnormalities of the p53 anti-oncogene are temporally related to the clinical progression of some cases of CML and are probably responsible for the development of blast crisis in these cases.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V77.11.2441.bloodjournal77112441