Synthesis, Characterisation and Antimicrobial Activity of Novel 2-Methyl-3-(2-(substituted ylidene)hydrazinyl)quinazolin-4(3H)-ones

Several novel quinazolinones were designed and synthesized from anthranilic acid by a multistep synthesis. Structures of synthesized compounds were well characterized using FT-IR, 1H-NMR, Mass spectroscopy and bases of elemental analysis. Entire test compounds were screened for their antibacterial a...

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Published inResearch journal of pharmacy and technology Vol. 15; no. 5; pp. 2176 - 2183
Main Authors Muthu Boopathi, Gopal, T. S., Shanmugarajan
Format Journal Article
LanguageEnglish
Published Raipur A&V Publications 30.05.2022
Subjects
Antimicrobial agents
Biological activity
Drug resistance
Ethanol
Hydrochloric acid
Pharmaceutical sciences
India
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Summary:Several novel quinazolinones were designed and synthesized from anthranilic acid by a multistep synthesis. Structures of synthesized compounds were well characterized using FT-IR, 1H-NMR, Mass spectroscopy and bases of elemental analysis. Entire test compounds were screened for their antibacterial and antifungal activities by agar streak dilution test against various pathogenic strains of bacteria and fungi. Antimicrobial studies revealed that all title compounds exhibited mild to good antibacterial activity and mild to moderate antifungal activity. The relationship between the functional group variation and the biological activity of the screened compounds were discussed. Out of thirteen tested analogs, the most active compound was found to be 3-(2-(1-(4-chlorophenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene) hydrazinyl)-2-methylquinazolin-4(3H)-one VIIg.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.52711/0974-360X.2022.00362