Preparation and Evaluation of Niosomal Transdermal Patch of Clozapine

Niosomes are the non-ionic surfactant vesicles obtained on hydration of synthetic non-ionic surfactants. These are the promising vehicles for effective transdermal drug delivery. The present research work was aimed to develop niosomal-based transdermal Clozapine patch containing a stable formulation...

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Bibliographic Details
Published inAsian Journal of Research in Pharmaceutical Science Vol. 13; no. 1; pp. 13 - 18
Main Authors Nagasree, K., Pallavi, K., Sri S, Ramya
Format Journal Article
LanguageEnglish
Published Raipur Athena Information Solutions Pvt. Ltd 21.03.2023
Subjects
Bioavailability
Cholesterol
Dopamine
Drug delivery systems
Drugs
Efficiency
Hydration
Particle size
Pharmacy
Schizophrenia
Solvents
Surfactants
Transdermal medication
Mumbai India
India
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Summary:Niosomes are the non-ionic surfactant vesicles obtained on hydration of synthetic non-ionic surfactants. These are the promising vehicles for effective transdermal drug delivery. The present research work was aimed to develop niosomal-based transdermal Clozapine patch containing a stable formulation with improved drug permeation. Niosomes were prepared by solvent casting method. All the formulations were evaluated for vesicle size, zeta potential and percent entrapment efficiency. All the patches were then characterized for thickness, folding endurance, drug content determination, Flatness, and in vitro permeation studies. F3 formulation having optimum vesicle size (2.6m), highest zeta potential (-32.56mV) and maximum percent entrapment efficiency (98.09%) was selected as optimized formulation. The transdermal patch was prepared using solvent casting method from the optimised niosomes formulation F3 formulation. The prepared optimised niosomes F3 formulation were loaded into the patch formulation. Patches loaded with niosomes (F3NT3) showed 95.78 % cumulative amount of drug permeated. The optimized formulation (F3NT3) followed first order release kinetics.
ISSN:2231-5640
2231-5659
DOI:10.52711/2231-5659.2023.00003