Lipid sensing and lipid sensors A new look at adipocyte lipid droplets: towards a role in the sensing of triacylglycerol stores?

Lipid droplets have been considered for a long time as inert intracytoplasmic deposits formed within cells under various conditions. Recently, new tools and new approaches have been used to visualize and study these intracellular structures. This revealed new aspects of lipid droplets biology and po...

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Bibliographic Details
Published inCellular and molecular life sciences : CMLS Vol. 64; no. 19-20; pp. 2452 - 2458
Main Authors Dugail, I., Hajduch, E.
Format Journal Article
LanguageEnglish
Published Basel Springer Nature B.V 01.10.2007
Birkhäuser-Verlag
Subjects
Biosensors
Cholesterol
Fatty acids
Lipids
Multi-author Review
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Summary:Lipid droplets have been considered for a long time as inert intracytoplasmic deposits formed within cells under various conditions. Recently, new tools and new approaches have been used to visualize and study these intracellular structures. This revealed new aspects of lipid droplets biology and pointed out their organized structure and dynamic composition. In adipocytes, the specialized cell type for the storage of energy as fat, lipid droplets are particularly well-developed organelles and exhibit unique properties. Also discussed in this paper is the view that lipid droplets, through specific candidate constituents, can play a role in sensing the level of their lipid stores by adipocytes. [PUBLICATION ABSTRACT]
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-007-7277-6