The correlation between severity of atopic dermatitis and serum levels of 25-hydroxyvitamin D, total IgE and IL-4 in children

• Published in: Pifu-xingbing zhenliaoxue zazhi Vol. 27; no. 4; pp. 227 - 231
• Main Authors: Xiao-ping PEI, Mei GU, Wen-jing CHEN, Yong-feng CHEN
• Format: Journal Article
• Language: Chinese
• Published: editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology 01.08.2020
• Subjects: 25-hydroxyvitamin d; atopic dermatitis; il-4; total immunoglobulin e
• ISSN: 1674-8468
• DOI: 10.3969/j.issn.1674-8468.2020.04.003

Objective: To explore the correlation between severity of atopic dermatitis (AD) and serum 25-hydroxyvitamin D [25(OH)D], total immunoglobulin E (tIgE) and IL-4 levels in children. Methods: A total of 160 children with AD who were treated in our hospital were enrolled. The severity of AD was evaluated and graded with the SCORAD score. Serum 25(OH) D levels were detected by high performance liquid chromatography, total IgE (tIgE) levels were detected by chemiluminescence, and IL-4 levels were detected by enzyme-linked immunosorbent assay. The correlation between serum 25(OH) D, tIgE, IL-4 level and SCORAD score were analyzed. Results: According to the SCORAD score, 55 cases (34.38%) were mild, 84 (52.50%) cases were moderate, and 21 (13.13%) cases were severe. The serum levels of 25(OH) D in children with AD were significantly negatively correlated with SCORAD score, serum tIgE and IL-4 levels all (r=-0.61, -0.48 and -0.33, respectively, all P<0.001). Furthermore, the SCORAD score were significantly positively correlated with serum tIgE and IL-4 levels (r=0.80, 0.71, respectively, both P<0.001). Conclusions: The serum 25(OH) D levels were negatively correlated with the severity of AD in children. Serum levels of 25(OH) D is a protective factor for AD. Serum tIgE and IL-4 levels were also negatively correlated with the severity of AD. Vitamin D may affect the severity of AD by affecting serum tIgE and regulating inflammatory factor IL-4 in skin immune regulation.