Bioorganic macromolecules crowned zirconia nanoparticles: protein-rich fish mucus inspired synthesis and their antibacterial efficacy assessment

• Published in: Zeitschrift für physikalische Chemie (Neue Folge)
• Main Authors: Subramanian, Ramasamy, Chinnadurai, Govindasamy, Suresh, Raman, Santhamoorthy, Madhappan, Periyasami, Govindasami, Karthikeyan, Perumal, Mohan, Anandhu, Vy Phan, Thi Tuong
• Format: Journal Article
• Language: English
• Published: 12.06.2024
• ISSN: 0942-9352; 2196-7156
• DOI: 10.1515/zpch-2023-0505

Abstract The bioinorganic material, such as fish mucus macromolecules crowned zirconia nanoparticles (ZrO 2 NPs) was synthesized via green methodology and has been investigated their efficacy on Gram-positive and Gram-negative bacterial strains that inhabit the oral cavity, gastrointestinal tracts, and colon. The environmentally benign synthesis methodology was used for fabricating biofunctionalized ZrO 2 NPs with three different concentrations of C. striatus epidermal mucus. Spherical morphology with a size ranging from 7 to 25 nm of synthesized granular was identified by FESEM analysis. The powder XRD diffractions of synthesized ZrO 2 NPs were confirmed with the previously reported standard literature. Upon being subjected to a primary microbial study, the synthesized ZrO 2 NPs were shown to exhibit antibacterial activity against the tested bacterial pathogens. However, another Gram-negative bacterial stain, Proteus vulgaris shows almost similar efficiency to standard antibacterial drugs. Interestingly, all Gram-positive bacterial strains show a high zone of inhibition at higher concentrations of synthesized ZrO 2  NPs. In general, the antibacterial activity study proved that the synthesized biofunctionalized ZrO 2 NPs may be applied as an efficient health care beneficial material.