Celastrol Alleviates Airway Hyperresponsiveness by Downregulating Th17 in Obese Asthmatic Mice

Methods Obese, ovalbumin-induced asthma (DIO-OVA) model was established by feeding mice with high fat diet for 16 weeks and sensitizing intraperitoneally with OVA on days 1 and 13 starting from week 12, followed by aerosol OVA challenge for 7 consecutive days on week 16. A correspondent increase of...

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Bibliographic Details
Published inJournal of allergy and clinical immunology Vol. 141; no. 2; p. AB283
Main Authors Zhang, Weixi, Zeng, Ze-Yu, Zhao, Wei
Format Journal Article
LanguageEnglish
Published St. Louis Elsevier Inc 01.02.2018
Elsevier Limited
Subjects
Asthma
Helper cells
Lymphocytes T
Obesity
Respiratory tract
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Summary:Methods Obese, ovalbumin-induced asthma (DIO-OVA) model was established by feeding mice with high fat diet for 16 weeks and sensitizing intraperitoneally with OVA on days 1 and 13 starting from week 12, followed by aerosol OVA challenge for 7 consecutive days on week 16. A correspondent increase of PC20 of MCh was noticed. [...]Celastrol treatment led to a significant decrease of splenic Th17 cell frequency (2.48 ± 1.14% vs 13.55 ± 2.12%, P<0.01) and serum Th17 concentration (66.24 ± 8.21 vs 145.19 ± 7.61 pg/ml, P<0.01).
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.901