Central role of danger signals in sepsis, trauma, and hemorrhage: insights from mathematical simulations

The innate immune response induced by these diverse insults is now thought to be driven by the recognition, through identical cell-surface molecules (the Toll-like receptors) of both pathogen-derived and (damaged) host-derived molecules that signal a state of "danger" to the host.

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Bibliographic Details
Published inJournal of critical care Vol. 20; no. 4; p. 390
Main Authors Vodovotz, Y., Billiar, T.R., Lagoa, C., Bartels, J., Baratt, A., Rubin, J., Fink, M.P., Clermont, G.
Format Journal Article
LanguageEnglish
Published Philadelphia Elsevier Inc 01.12.2005
Elsevier Limited
Subjects
Mathematical models
Medical research
Sepsis
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Summary:The innate immune response induced by these diverse insults is now thought to be driven by the recognition, through identical cell-surface molecules (the Toll-like receptors) of both pathogen-derived and (damaged) host-derived molecules that signal a state of "danger" to the host.
ISSN:0883-9441
1557-8615
DOI:10.1016/j.jcrc.2005.09.038