High Efficiency Activation of L-Type Ca 2+ Current by 5-HT in Human Atrial Myocytes

In human atrial myocytes, serotonin rather than sympathetic, stimulation is more frequently associated with atrial fibrillation. So does the arrhythmogenic effect of serotonin result from the mechanism of action of the receptor or the context of its action upon cardiac myocytes? The capacity of agon...

Full description

Saved in:
Bibliographic Details
Published inReceptors & channels Vol. 10; no. 5-6; pp. 159 - 165
Main Authors Scala, Emmanuella Di, Findlay, Ian, Rose, Stephanie, Aupart, Michel, Argibay, Jorge, Cosnay, Pierre, Bozon, Veronique
Format Journal Article
LanguageEnglish
Published Informa UK (Taylor & Francis) 01.01.2004
Subjects
Endocrinology and metabolism
Human health and pathology
Life Sciences
atrial fibrillation
serotonin
cAMP
human atrial myocytes
Ca current
Online AccessGet full text

Cover

More Information
Summary:In human atrial myocytes, serotonin rather than sympathetic, stimulation is more frequently associated with atrial fibrillation. So does the arrhythmogenic effect of serotonin result from the mechanism of action of the receptor or the context of its action upon cardiac myocytes? The capacity of agonists to produce cAMP followed the sequence 5-HT < Iso < Forskolin to increase ICaL with 5-HT = Iso = Forskolin. The simultaneous application of threshold concentrations of 5-HT and Iso maximally increased ICaL. We will show that the effect of 5-HT upon human atrial myocytes is an imbalance between low production of cAMP and maximal activation of ICaL.
ISSN:1060-6823
1543-5334
DOI:10.3109/10606820490926115