High Efficiency Activation of L-Type Ca 2+ Current by 5-HT in Human Atrial Myocytes
In human atrial myocytes, serotonin rather than sympathetic, stimulation is more frequently associated with atrial fibrillation. So does the arrhythmogenic effect of serotonin result from the mechanism of action of the receptor or the context of its action upon cardiac myocytes? The capacity of agon...
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Published in | Receptors & channels Vol. 10; no. 5-6; pp. 159 - 165 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Informa UK (Taylor & Francis)
01.01.2004
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Subjects | |
Online Access | Get full text |
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Summary: | In human atrial myocytes, serotonin rather than sympathetic, stimulation is more frequently associated with atrial fibrillation. So does the arrhythmogenic effect of serotonin result from the mechanism of action of the receptor or the context of its action upon cardiac myocytes? The capacity of agonists to produce cAMP followed the sequence 5-HT < Iso < Forskolin to increase ICaL with 5-HT = Iso = Forskolin. The simultaneous application of threshold concentrations of 5-HT and Iso maximally increased ICaL. We will show that the effect of 5-HT upon human atrial myocytes is an imbalance between low production of cAMP and maximal activation of ICaL. |
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ISSN: | 1060-6823 1543-5334 |
DOI: | 10.3109/10606820490926115 |