Inheritance of PiM Subtypes

Pi phenotypes were classified by isoelectric focusing in sera of 151 families with a total of 242 children and in sera of 142 mother-child pairs. The six common subtypes of PiM are genetically determined by three alleles named Pi M1 , Pi M2 , and Pi M3 . No exceptions to the postulated mode of inher...

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Bibliographic Details
Published inHuman heredity Vol. 29; no. 6; pp. 351 - 354
Main Authors Cleve, H., Patutschnick, W., Strecker, K., Nevo, S.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland 29.08.2008
Subjects
Original Paper
Pi system
Inheritance
PiM subtypes
Isoelectric focusing
α1-Antitrypsin
Protease inhibitor
Family data
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Summary:Pi phenotypes were classified by isoelectric focusing in sera of 151 families with a total of 242 children and in sera of 142 mother-child pairs. The six common subtypes of PiM are genetically determined by three alleles named Pi M1 , Pi M2 , and Pi M3 . No exceptions to the postulated mode of inheritance have been found. The possibility of further heterogeneity of the intermediate variant PiM3 is discussed.
ISSN:0001-5652
1423-0062
DOI:10.1159/000153071