Transport of Amino Acids into the Lens in the Course of Experimental Diabetic Cataract

Pathological modifications of both active and passive transport processes have been studied in the evolution of strepto-zotocin diabetic cataracts in rats. During the cataract development, it has been shown a large decrease, in and at times a disappearance of active transport for a neutral amino aci...

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Bibliographic Details
Published inOphthalmic research Vol. 4; no. 2; pp. 114 - 121
Main Authors Laurent, M., Kern, P., Regnault, F.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland 09.12.2009
Subjects
Kinetic experiments
Cataract
Rat
Amino acids
Lens
Diabetes
Transport
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Summary:Pathological modifications of both active and passive transport processes have been studied in the evolution of strepto-zotocin diabetic cataracts in rats. During the cataract development, it has been shown a large decrease, in and at times a disappearance of active transport for a neutral amino acid (glycine). The apparent dissociation constant between carrier and substrate also decreased during the evolution process. Another characteristic feature of cataract development is a great increase of passive permeability for the two amino acids glycine and glutamic acid. The relation between the observed disturbance of passive diffusion in diabetic cataract and biochemical disturbances in structural components of lens capsule is evaluated.
ISSN:0030-3747
1423-0259
DOI:10.1159/000265962