Leukozyten-Adhäsionsmoleküle bei chronisch-entzündlichen Erkrankungen der Hornhaut

Using immunohistochemical techniques, we investigated the expression of leukocyte adhesion molecules – intercellular adhesion molecule-1 (ICAM-1), E-selectin (endothelial leukocyte adhesion molecule-1), and vascular cell adhesion molecule-1 (VCAM-1) – in various chronic inflammatory corneal diseases...

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Bibliographic Details
Published inOphthalmologica (Basel) Vol. 207; no. 1; pp. 19 - 29
Main Authors Philipp, Wolfgang, Göttinger, Wolfgang
Format Journal Article
LanguageEnglish
Published Basel, Switzerland 01.01.1993
Subjects
Original Paper
molecule-1 Vascular cell adhesion
Intercellular adhesion
leukocyte adhesion
molecule-1 E-selectin endothelial
molecule-1 Cornea
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Summary:Using immunohistochemical techniques, we investigated the expression of leukocyte adhesion molecules – intercellular adhesion molecule-1 (ICAM-1), E-selectin (endothelial leukocyte adhesion molecule-1), and vascular cell adhesion molecule-1 (VCAM-1) – in various chronic inflammatory corneal diseases of different etiology. ICAM-1 was focally expressed on epithelial cells and showed an increased expression, on keratocytes, corneal endothelial cells, and vascular endothelial cells. E-selectin was present on vascular endothelial cells of several corneas, while VCAM-1 was found particularly on macrophages and only sporadically on vascular endothelial cells. Our results suggest that ICAM-1, E-selectin, and VCAM-1 may be involved in the pathogenesis of various chronic inflammatory corneal diseases, particularly in the selective recruitment of different leukocyte populations.
ISSN:0030-3755
1423-0267
DOI:10.1159/000310401