Unusual withanolides from Physalis hispida (Waterf.) cronquist
Withanolides are a group of modified C 28 ergostane-type steroids with a C-22, C-26 δ -lactone side chain. As part of our continuing search for unusual withanolides for SAR studies, we isolated and characterized nine new withanolides ( 1 - 9 ), withahisolides A-I, as well as nine known compounds ( 1...
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| Published in | Planta Medica |
|---|---|
| Main Authors | , , , |
| Format | Conference Proceeding |
| Language | English |
| Published |
25.06.2015
|
| Online Access | Get full text |
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| Summary: | Withanolides are a group of modified C
28
ergostane-type steroids with a C-22, C-26
δ
-lactone side chain. As part of our continuing search for unusual withanolides for SAR studies, we isolated and characterized nine new withanolides (
1
-
9
), withahisolides A-I, as well as nine known compounds (
10
-
18
) from the aerial parts of
Physalis hispida
. The structures of
1
-
9
were elucidated through a variety of spectroscopic techniques, while those of
1
and
2
were further confirmed by X-ray crystallographic analysis. Among the eight new withanolides (
1
-
7
,
9
) with an unusual six-membered ring D,
1
-
3
are the first withanolides possessing non-aromatic six-membered ring D moieties. In addition, withanolide
8
represents a novel withanolide skeleton due to the absence of a C-13-C-17 bond within its steroidal nucleus. |
|---|---|
| ISSN: | 0032-0943 1439-0221 |
| DOI: | 10.1055/s-0035-1556167 |