Could antisense oligonucleotides targeted to K-ras gene inhibit the tumor growth, invasiveness and expression of MMP-2 and MMP-9 in vitro and in vivo in hamster experimental pancreatic cancer model?

Ras activates a multitude of downstream activities with roles in cellular processing, including invasion and metastasis. [...]antisense oligonucleotides (ASO) targeting this K-ras gene may be a therapeutic approach. Spontaneous lymph node metastases were found from 31 days in ATH group, while PC and...

Full description

Saved in:
Bibliographic Details
Published inPancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Vol. 17; no. 4; p. S48
Main Authors Morioka, Cintia, Veiga da Silva, Joelmir, Pereira, Nixon Silva, Otoch, Jose Pinhata, Machado, Marcel Cerqueira Cesar, Garcia, Marcelo Engracia, Rodrigues Lima, Edgard Mesquita, Borges, Gustavo
Format Journal Article
LanguageEnglish
Published Philadelphia Elsevier B.V 01.09.2017
Elsevier Limited
Subjects
Antisense oligonucleotides
Gelatinase A
Gelatinase B
Invasiveness
K-Ras protein
Lymph nodes
Metastasis
Pancreatic cancer
Online AccessGet full text

Cover

More Information
Summary:Ras activates a multitude of downstream activities with roles in cellular processing, including invasion and metastasis. [...]antisense oligonucleotides (ASO) targeting this K-ras gene may be a therapeutic approach. Spontaneous lymph node metastases were found from 31 days in ATH group, while PC and STH groups showed metastases and direct invasion to adjacent organs from 17 days.After death, metastatic sites were similar in 3 groups.ASO downregulated the activation of MMP-9, more than MMP-2 in vivo.
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2017.07.157