Could antisense oligonucleotides targeted to K-ras gene inhibit the tumor growth, invasiveness and expression of MMP-2 and MMP-9 in vitro and in vivo in hamster experimental pancreatic cancer model?
Ras activates a multitude of downstream activities with roles in cellular processing, including invasion and metastasis. [...]antisense oligonucleotides (ASO) targeting this K-ras gene may be a therapeutic approach. Spontaneous lymph node metastases were found from 31 days in ATH group, while PC and...
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Published in | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Vol. 17; no. 4; p. S48 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Philadelphia
Elsevier B.V
01.09.2017
Elsevier Limited |
Subjects | |
Online Access | Get full text |
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Summary: | Ras activates a multitude of downstream activities with roles in cellular processing, including invasion and metastasis. [...]antisense oligonucleotides (ASO) targeting this K-ras gene may be a therapeutic approach. Spontaneous lymph node metastases were found from 31 days in ATH group, while PC and STH groups showed metastases and direct invasion to adjacent organs from 17 days.After death, metastatic sites were similar in 3 groups.ASO downregulated the activation of MMP-9, more than MMP-2 in vivo. |
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ISSN: | 1424-3903 1424-3911 |
DOI: | 10.1016/j.pan.2017.07.157 |