2736 THE PHASE ANGLE AS A PREDICTOR OF SARCOPENIA IN NORMOHYDRATED PATIENTS ON HEMODIALYSIS: A MULTICENTER STUDY

• Published in: Nephrology, dialysis, transplantation Vol. 38; no. Supplement_1
• Main Authors: López, Yanet Parodis, Ortega, Sebastian Hillebrand, Alman, Francisco Alonso, Vega, Nicanor, Anton-Perez, Gloria
• Format: Journal Article
• Language: English
• Published: 14.06.2023
• ISSN: 0931-0509; 1460-2385
• DOI: 10.1093/ndt/gfad063d_2736

Abstract Background and Aims The skeletal muscle index (SMI) is an impedance parameter that assesses muscle mass, and the phase angle (PA) is inversely related to strength and muscle mass in hemodialysis patients. Both parameters may represent useful and inexpensive tools to identify sarcopenic patients. Method The presence of sarcopenia was analyzed in 348 normohydrated patients in 5 hemodialysis centers by means of vector bioimpedance using the BIA101 BIVA PRO equipment. To do this, the skeletal muscle index (SMI) and the phase angle (PA) are evaluated as markers of muscle mass and strength, respectively. Results Mean SMI and PA were 8.64 ± 1.5 and 5.2 ± 0.9. The mean PA was 5.6 ± 0.9 in those with SMI within normality (9.2 ± 1.9) (p<0.001). In moderate and severe sarcopenics patients, the means of SMI (8.9 ± 1.2 vs 7.5 ± 0.9) and PA (5.3 ± 0.86 vs 4.7 ± 0.67) were significantly lower (p < 0.001) (Table 1). In patients on standard hemodialysis, the PA (P = .02) and the SMI (P = .004) were significantly lower. The PA (P = .014) and the SMI (p < 0.01) were significantly lower in the female gender but the number of sarcopenic patients was higher among the men (p< 0.001). The cut-off value of PA, which predicted a higher risk of sarcopenia, was 3.5 in all patients (95% CI, 0.60-0.71; P = .0001; 100% sensitivity, 96% specificity ); 3.55 for men (95% CI, 0.57-0.78; P = .003; 100% sensitivity, 94% specificity) and 3.65 for women (95% CI, 0.60-0.73 ; P = .0001; 100% sensitivity, 96% specificity) (Fig. 1). In the logistic regression analysis, male gender, standard hemodialysis technique, and PA were associated with a higher risk of sarcopenia (Table 2). Conclusion PA is a good predictor of sarcopenia in hemodialysis patients.