Chemical Constituents From The Aerial Parts Of Zehneria Scabra Sond

• Published in: Planta Medica
• Main Authors: Ayam, VS, Ali, Z, Khan, IA, Ross, SA
• Format: Conference Proceeding
• Language: English
• Published: 17.03.2016
• ISSN: 0032-0943; 1439-0221
• DOI: 10.1055/s-0036-1578714

Zehneria (Cucurbitaceae) is a tropical and subtropical dioecious, perennial vine that consists of approximately 35 species. Zehneria is used in folk medicine for the treatment of skin diseases, diabetes and jaundice in Africa and India. Phytochemical investigation of the aerial parts of Zehneria scabra Sond. resulted in the isolation and structure elucidation of two new compounds: 3,10-dihydroxy-5,6-epoxy-β-ionol ( 1 ) and 3,10-dihydroxy-5,6-epoxy-β-ionyl-10-O-β-D-glucopyranoside ( 2 ) with five known compounds ( 3 - 7 ), which are reported for the first time from this plant species. The known compounds were identified as cucumegastigmane I ( 3 ), corchoionoside C ( 4 ) ; indole-3-carboxylic acid ( 5 ), methyl indole-3-carboxylate ( 6 ) and benzyl-O-β-D-glucopyranoside ( 7 ) by their NMR, HRESIMS spectral data analyses, as well as on comparison with reported values [1 – 4]. Fig. 1 Acknowledgements: We are grateful to the Department of Biotechnology, Government of India and the National Center for Natural Products Research, The University of Mississippi, USA for financial support. Also thanks to Brajakishore Singh, Institute of Bio-resources and Sustainable Development, Imphal, Manipur, India for initial extraction facility. References: [1] Okuyama T, Kai H, et al. (2007) Chem. Pharm. Bull. 55:133 – 136. [2] Yoshikawa M, Shimada H, et al. (1997) Chem Pharm Bull 45:464 – 469. [3] Hu SC, Tan RX, et al. (2005) Acta Cryst 61:16540 – 1656. [4] Lorizzi M, de Marino S, et al. (2009) Phytochemistry Letters 2:130 – 133.