Biological and chemical study of two Indonesian marine endophytic fungi

• Published in: Planta Medica
• Main Authors: Tarman, K, Palm, GJ, Wende, K, Lindequist, U
• Format: Conference Proceeding
• Language: English
• Published: 05.08.2011
• ISSN: 0032-0943; 1439-0221
• DOI: 10.1055/s-0031-1282194

In the search for biologically active natural products from Indonesian marine sources two strains of marine endophytic fungi could be isolated from the marine red alga Kappaphycus alvarezii . One strain (KT 30) could be identified as Xylaria psidii , the other one (KT 31) remains sterile and could not be identified till now. Ethylacetate extracts from the culture medium displayed considerable cytotoxic activity against a urinary bladder carcinoma cell line with IC 50 values of 4 and 1.5µg/ml, respectively. Both strains were also obviously active to inhibit the growth of fish and human pathogenic microorganisms. Most remarkable is the strong antimicrobial activity of ethylacetate extracts against the gram-negative bacteria Pseudomonas aeruginosa, Escherichia coli, Vibrio anguillarum and Aeromonas salmonicida . A new cyanomethoxy benzoic acid derivative was isolated from X. psidii KT30 and a new quinone derivative from the algicolous fungus KT31. Besides, cytochalasin B was detected for the first time in X. psidii . Keywords: Indonesian marine fungi, algicolous, antifungal, cytotoxic Acknowledgement: We thank PD Dr. Marc Stadler (InterMedDiscovery, Dortmund, Germany) for identification of the Xylaria species.