The expression and activation of the AIM2 inflammasome correlates with inflammation and disease severity in patients with acute pancreatitis

Results: Our results show that PBMCs from patients with acute pancreatitis have elevated expression of several components of the inflammasome complex, including the inflammasome-forming receptor absent in melanoma 2 (AIM2), early during the onset of the disease. [...]AIM2 expression was further incr...

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Published inPancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Vol. 17; no. 5; pp. S5 - S6
Main Authors Algaba Chueca, F., de Madaria, E., Lozano Ruiz, B., Martínez Cardona, C., Bachiller, V., Tarín, F., Such, J.
Format Journal Article
LanguageEnglish
Published Philadelphia Elsevier B.V 01.09.2017
Elsevier Limited
Subjects
Cytokines
Inflammasomes
Inflammation
Pancreatitis
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Summary:Results: Our results show that PBMCs from patients with acute pancreatitis have elevated expression of several components of the inflammasome complex, including the inflammasome-forming receptor absent in melanoma 2 (AIM2), early during the onset of the disease. [...]AIM2 expression was further increased in those patients that developed transient or persistent organ failure (moderate or severe acute pancreatitis).
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2017.08.027