The evaluation of wound healing potential of acetyl alkannin isolated from Arnebia purpurea
Medicinal plants containing alkannin/shikonin and their derivatives have been used for wound healing treatment for years. Arnebia (Boraginaceae) species have these compounds in high quantity. Previous studies showed the root extract of Arnebia spec. and alkannin derivatives have wound healing, antii...
Saved in:
Published in | Planta Medica |
---|---|
Main Authors | , , , , , , , |
Format | Conference Proceeding |
Language | English |
Published |
25.11.2015
|
Online Access | Get full text |
Cover
Loading…
Abstract | Medicinal plants containing alkannin/shikonin and their derivatives have been used for wound healing treatment for years.
Arnebia
(Boraginaceae) species have these compounds in high quantity. Previous studies showed the root extract of
Arnebia
spec. and alkannin derivatives have wound healing, antiinflammatory, antitumoral, antibacterial and antifungal effects [1,2]. In this study, acetyl alkannin, the major naphthoquinone isolated from the roots
n
-hexane extract of
Arnebia purpurea
S. Erik & H. Sümbül which is an endemic species in Turkey have investigated in terms of its wound healing activity. Acetyl alkannin in PBS suspension (120 mg/kg, 0.1%) applied topically on both excision normal wound model and hydrocortisone-induced impaired wound model [3 – 4]. When our results were analyzed histopathologically (lymphocyte density, vascular proliferation, edema formation and fibrosis), acetyl alkannin applied groups had a statistically significant effect on all type wound healing phases compared with the control groups (p < 0.05, ANOVA test).
References:
[1] Yuzbasioglu M, Kuruuzum-Uz A. Uses and biological activities of
Arnebia sp.
Hacettepe Univ J of Fac Pharm 2012; 32: 91 – 106
[2] Papageorgiou VP, Assimopoulou AN, Ballis AC. Alkannins and shikonins: a new class of wound healing agents. Curr Med Chem 2008; 15: 3248 – 3267.
[3] Dorsett-Martin WA. Rat models of skin wound healing: a review. Wound Repaır Regen 2004, 12: 591 – 599.
[4] Sidhu GZ, Singh AK, Banaudha KK, Gaddipati JP, Patnaik GK, Maheshwari RK. J Invest Dermatol 1999; 113: 773 – 781 |
---|---|
AbstractList | Medicinal plants containing alkannin/shikonin and their derivatives have been used for wound healing treatment for years.
Arnebia
(Boraginaceae) species have these compounds in high quantity. Previous studies showed the root extract of
Arnebia
spec. and alkannin derivatives have wound healing, antiinflammatory, antitumoral, antibacterial and antifungal effects [1,2]. In this study, acetyl alkannin, the major naphthoquinone isolated from the roots
n
-hexane extract of
Arnebia purpurea
S. Erik & H. Sümbül which is an endemic species in Turkey have investigated in terms of its wound healing activity. Acetyl alkannin in PBS suspension (120 mg/kg, 0.1%) applied topically on both excision normal wound model and hydrocortisone-induced impaired wound model [3 – 4]. When our results were analyzed histopathologically (lymphocyte density, vascular proliferation, edema formation and fibrosis), acetyl alkannin applied groups had a statistically significant effect on all type wound healing phases compared with the control groups (p < 0.05, ANOVA test).
References:
[1] Yuzbasioglu M, Kuruuzum-Uz A. Uses and biological activities of
Arnebia sp.
Hacettepe Univ J of Fac Pharm 2012; 32: 91 – 106
[2] Papageorgiou VP, Assimopoulou AN, Ballis AC. Alkannins and shikonins: a new class of wound healing agents. Curr Med Chem 2008; 15: 3248 – 3267.
[3] Dorsett-Martin WA. Rat models of skin wound healing: a review. Wound Repaır Regen 2004, 12: 591 – 599.
[4] Sidhu GZ, Singh AK, Banaudha KK, Gaddipati JP, Patnaik GK, Maheshwari RK. J Invest Dermatol 1999; 113: 773 – 781 |
Author | Bali, YY Unlu, RE Yuzbasioglu, M Orhan, E Guvenalp, Z Yilanci, S Demirezer, LO Kuruuzum Uz, A |
Author_xml | – sequence: 1 givenname: YY surname: Bali fullname: Bali, YY organization: Plastic and Reconstructive Surgery, Ankara Numune Training and Research Hospital, Ankara, Turkey – sequence: 2 givenname: S surname: Yilanci fullname: Yilanci, S organization: Plastic and Reconstructive Surgery, Ankara Numune Training and Research Hospital, Ankara, Turkey – sequence: 3 givenname: M surname: Yuzbasioglu fullname: Yuzbasioglu, M organization: Hacettepe University, Faculty of Pharmacy, Department of Pharmacognosy, 06100, ANKARA, Turkey – sequence: 4 givenname: RE surname: Unlu fullname: Unlu, RE organization: Plastic and Reconstructive Surgery, Ankara Numune Training and Research Hospital, Ankara, Turkey – sequence: 5 givenname: E surname: Orhan fullname: Orhan, E organization: Plastic Surgery, Namik Kemal University, Faculty of Medicine, 59860, Tekirdag, Turkey – sequence: 6 givenname: Z surname: Guvenalp fullname: Guvenalp, Z organization: Department of Pharmacognosy, Faculty of Pharmacy, University of Atatürk, 25240, Erzurum, Turkey – sequence: 7 givenname: LO surname: Demirezer fullname: Demirezer, LO organization: Hacettepe University, Faculty of Pharmacy, Department of Pharmacognosy, 06100, ANKARA, Turkey – sequence: 8 givenname: A surname: Kuruuzum Uz fullname: Kuruuzum Uz, A organization: Hacettepe University, Faculty of Pharmacy, Department of Pharmacognosy, 06100, ANKARA, Turkey |
BookMark | eNotkEtLAzEUhYNUsK1uXecPRG8mjzHLUnxBwU1duRjuzNzY1DQp81D8906xcOEsPjjn8i3YLOVEjN1KuJNgzH0vAJQR0lijnLxgc6mVE1AUcsbmEyoEOK2u2KLv9wBSO4A5-9juiNM3xhGHkBPPnv_kMbV8RxhD-uTHPFAaAsYTwoaG38gxfmFKIfHQ54gDtdx3-cBXXaI6ID-O3XSE1-zSY-zp5pxL9v70uF2_iM3b8-t6tRGNnJ4TDlun0GCpwUlvsUHf2gfrygbrspRWTxDaWpPXrbSNqaVTGlCZQltvSKklE_-9wy7Qgap9Hrs0DVYSqpOZqq9OZqqzGfUH9NBY1w |
CitedBy_id | crossref_primary_10_1016_j_biopha_2019_108782 crossref_primary_10_29133_yyutbd_1306035 |
ContentType | Conference Proceeding |
DBID | 0U6 |
DOI | 10.1055/s-0035-1565391 |
DatabaseName | Thieme Connect Journals Open Access |
DatabaseTitleList | |
Database_xml | – sequence: 1 dbid: 0U6 name: Thieme Connect Journals Open Access url: http://open.thieme.com sourceTypes: Publisher |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Pharmacy, Therapeutics, & Pharmacology Botany |
EISSN | 1439-0221 |
ExternalDocumentID | 10_1055_s_0035_1565391 |
GroupedDBID | --- -~X 0R~ 0U6 123 1UC 4.4 53G 5~~ AAMFZ AAWTL AAYOK ABOCM ABPTK ACGFS AECCQ AEDKO AEILP AEMDM AENEX AEUVB AFUVZ AFZED AHRAW ALMA_UNASSIGNED_HOLDINGS BXHMU CS3 DU5 EBS EJD EWXKU F5P H13 IY8 L7B N9A O9- QTC RN7 RTC ~KM |
ID | FETCH-LOGICAL-c1221-9ad93a5a74091f6acafd68697cab771643a50db4ef4d16c5b19340a35246f5e33 |
IEDL.DBID | 0U6 |
ISSN | 0032-0943 |
IngestDate | Fri Aug 04 23:39:42 EDT 2023 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Language | English |
LinkModel | DirectLink |
MeetingName | GA 2015 – Book of Abstracts - Budapest, Hungary - 2015 |
MergedId | FETCHMERGED-LOGICAL-c1221-9ad93a5a74091f6acafd68697cab771643a50db4ef4d16c5b19340a35246f5e33 |
OpenAccessLink | http://dx.doi.org/10.1055/s-0035-1565391 |
ParticipantIDs | thieme_journals_10_1055_s_0035_1565391 |
PublicationCentury | 2000 |
PublicationDate | 20151125 |
PublicationDateYYYYMMDD | 2015-11-25 |
PublicationDate_xml | – month: 11 year: 2015 text: 20151125 day: 25 |
PublicationDecade | 2010 |
PublicationTitle | Planta Medica |
PublicationTitleAlternate | Planta Med |
PublicationYear | 2015 |
SSID | ssj0014900 |
Score | 2.1612172 |
Snippet | Medicinal plants containing alkannin/shikonin and their derivatives have been used for wound healing treatment for years.
Arnebia
(Boraginaceae) species have... |
SourceID | thieme |
SourceType | Publisher |
Title | The evaluation of wound healing potential of acetyl alkannin isolated from Arnebia purpurea |
URI | http://dx.doi.org/10.1055/s-0035-1565391 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3PS8MwFA4yPXjTOfE3OchOK3ZpXtYcVRxDUHbYYOChJE2Cw9mNtSL9733p6ip6EXoovLaH15TvS9_7vkfINYsts47JwLFYBTzCMy2VDnRkjMMDQcILnJ-exWjKH2cwa_53_K7gA9zkQWWriPsMiLxMfZchxPnmrXAqtvUCLmuxScQC3yv3bc_4534EmuJ1bt_tDxQZHpBOo6-j4y1yHJIdm7XJ3t0SiVrZJt3xxk667NFJo47Ke7RLx43RdHlEXjBMG7tuunT0009Jop794YPpaln4ZiC18CGV2qJcULV4q8YU0TmuOiSahnqFCb1dZ1bPFV1h4n2jeodMhw-T-1FQD0sI0j7zbRbKyEiBGuCGre-ESpUzIhZykCo98JsiDIZGc-u46YsUNDI3HirkX1w4sFF0TFrZMrMnhBpwDHQIBr9mzpiOQWphAJwEBbEMT0l3k8OkXu95UpWyAZLce41CUif77L8XnpN9JCLgNX4MLkirWH_YSwT7Ql9V7_kLU3CjVw |
link.rule.ids | 310,311,786,790,795,796,20918,23958,23959,25170,27958 |
linkProvider | Thieme |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=proceeding&rft.title=Planta+Medica&rft.atitle=The+evaluation+of+wound+healing+potential+of+acetyl+alkannin+isolated+from+Arnebia+purpurea&rft.au=Bali%2C+YY&rft.au=Yilanci%2C+S&rft.au=Yuzbasioglu%2C+M&rft.au=Unlu%2C+RE&rft.date=2015-11-25&rft.issn=0032-0943&rft.eissn=1439-0221&rft_id=info:doi/10.1055%2Fs-0035-1565391&rft.externalDBID=HTML_FULL_TEXT&rft.externalDocID=10_1055_s_0035_1565391 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0032-0943&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0032-0943&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0032-0943&client=summon |