The evaluation of wound healing potential of acetyl alkannin isolated from Arnebia purpurea

• Published in: Planta Medica
• Main Authors: Bali, YY, Yilanci, S, Yuzbasioglu, M, Unlu, RE, Orhan, E, Guvenalp, Z, Demirezer, LO, Kuruuzum Uz, A
• Format: Conference Proceeding
• Language: English
• Published: 25.11.2015
• ISSN: 0032-0943; 1439-0221
• DOI: 10.1055/s-0035-1565391

Medicinal plants containing alkannin/shikonin and their derivatives have been used for wound healing treatment for years. Arnebia (Boraginaceae) species have these compounds in high quantity. Previous studies showed the root extract of Arnebia spec. and alkannin derivatives have wound healing, antiinflammatory, antitumoral, antibacterial and antifungal effects [1,2]. In this study, acetyl alkannin, the major naphthoquinone isolated from the roots n -hexane extract of Arnebia purpurea S. Erik & H. Sümbül which is an endemic species in Turkey have investigated in terms of its wound healing activity. Acetyl alkannin in PBS suspension (120 mg/kg, 0.1%) applied topically on both excision normal wound model and hydrocortisone-induced impaired wound model [3 – 4]. When our results were analyzed histopathologically (lymphocyte density, vascular proliferation, edema formation and fibrosis), acetyl alkannin applied groups had a statistically significant effect on all type wound healing phases compared with the control groups (p < 0.05, ANOVA test). References: [1] Yuzbasioglu M, Kuruuzum-Uz A. Uses and biological activities of Arnebia sp. Hacettepe Univ J of Fac Pharm 2012; 32: 91 – 106 [2] Papageorgiou VP, Assimopoulou AN, Ballis AC. Alkannins and shikonins: a new class of wound healing agents. Curr Med Chem 2008; 15: 3248 – 3267. [3] Dorsett-Martin WA. Rat models of skin wound healing: a review. Wound Repaır Regen 2004, 12: 591 – 599. [4] Sidhu GZ, Singh AK, Banaudha KK, Gaddipati JP, Patnaik GK, Maheshwari RK. J Invest Dermatol 1999; 113: 773 – 781