Antihepatitis B virus constituents from Solanum erianthum
Eleven constituents including α-linolenic acid ( 1 ), 13 S -hydroxy-9( Z ),11( E )-octadecadienoic acid ( 2 ), 9 S -hydroxy-10( E ),12( Z ),15( Z )-octadectrienoic acid ( 3 ), 9( Z ),11( E )-octadecadienoic acid ( 4 ), octadecanoic acid ( 5 ), loliolide ( 6 ), dihydroactinidiolide ( 7 ), solasonine...
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| Published in | Planta Medica |
|---|---|
| Main Authors | , , , , |
| Format | Conference Proceeding |
| Language | English |
| Published |
19.07.2012
|
| Online Access | Get full text |
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| Summary: | Eleven constituents including α-linolenic acid (
1
), 13
S
-hydroxy-9(
Z
),11(
E
)-octadecadienoic acid (
2
), 9
S
-hydroxy-10(
E
),12(
Z
),15(
Z
)-octadectrienoic acid (
3
), 9(
Z
),11(
E
)-octadecadienoic acid (
4
), octadecanoic acid (
5
), loliolide (
6
), dihydroactinidiolide (
7
), solasonine (
8
), solamargine (
9
), camelliaside C (
10
), 5-methoxy-(3'',4''-dihydro-3'',4''-diacetoxy)-2'',2''-dimethylpyrano-(7,8:5'',6'')-flavone (
11
) were isolated from title plant.
9
showed the most potent activity against HBsAg (IC
50
: 1.57µM).
11
was the only active constituent (IC
50
: 36.11µM) against HBeAg.
9
revealed strong inhibition in DNA replication (IC
50
: 2.17µM).
1
showed prominent selected index (SI) in anti-HBsAg (7.75) and inhibition of DNA replication (7.18). This is the first report that unsaturated fatty acid
1
, steroidal alkaloid glycoside
9
and flavone
11
, showed excellent activity against HBV. |
|---|---|
| ISSN: | 0032-0943 1439-0221 |
| DOI: | 10.1055/s-0032-1320891 |