Analgesic and Anti-Inflammatory Activities of the Ethanolic Extract of Artemisia Morrisonesis Hayata in Mice

The aim of this study was to investigate the analgesic/anti-inflammatory mechanisms of the ethanolic extract of A. morrisonensis Hayata (AM EtOH ). AM EtOH decreased writhing response for acetic acid assay and the licking time in the formalin test. The results indicated that the anti-inflammatory me...

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Bibliographic Details
Published inPlanta Medica
Main Authors Chou, SC, Chiu, YJ, Chen, CJ, Lin, YC, Wu, CH, Chao, CT, Chang, CW, Peng, WH
Format Conference Proceeding
LanguageEnglish
Published 04.07.2013
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Summary:The aim of this study was to investigate the analgesic/anti-inflammatory mechanisms of the ethanolic extract of A. morrisonensis Hayata (AM EtOH ). AM EtOH decreased writhing response for acetic acid assay and the licking time in the formalin test. The results indicated that the anti-inflammatory mechanism of AM EtOH may be due to the declined levels of NO and MDA in the edematous paw. AM EtOH decreased the TNF-α and IL-6 levels, leading to the reduction of prostaglandins and subsequently alleviated edema. Isolation and purification of the AM EtOH extract determined p -hydroxyacetophenone to be a major component at 130 mg/g of extract. This study demonstrated the possible mechanisms for analgesic/anti-inflammatory effects of AM EtOH for mice.
ISSN:0032-0943
1439-0221
DOI:10.1055/s-0033-1348690