2 H -Pyranone and isocoumarin derivatives isolated from the plant pathogenic fungus Leptosphaena maculans

Two new 2 -pyranones and two new isocoumarin derivatives, maculanslines A-D ( ), together with seven known compounds ( ), were isolated from the plant pathogenic fungus . Their planar structures and absolute configuration were elucidated by comprehensive spectroscopic techniques including high-resol...

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Bibliographic Details
Published inJournal of asian natural products research Vol. 21; no. 10; pp. 939 - 946
Main Authors Liao, Ming-Fang, Wang, Kai, Ren, Jin-Wei, Liu, Li, Cai, Lei, Han, Jun-Jie, Liu, Hong-Wei
Format Journal Article
LanguageEnglish
Published England 03.10.2019
Subjects
Circular Dichroism
Fungi - chemistry
Glycoside Hydrolase Inhibitors - chemistry
Glycoside Hydrolase Inhibitors - pharmacology
Isocoumarins - analysis
Isocoumarins - isolation & purification
Isocoumarins - pharmacology
Magnetic Resonance Spectroscopy
Molecular Structure
Plant Diseases
Pyrans - analysis
Pyrans - pharmacology
Spectrometry, Mass, Electrospray Ionization
isocoumarins
2-pyranones
inhibition of -glucosidase
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Summary:Two new 2 -pyranones and two new isocoumarin derivatives, maculanslines A-D ( ), together with seven known compounds ( ), were isolated from the plant pathogenic fungus . Their planar structures and absolute configuration were elucidated by comprehensive spectroscopic techniques including high-resolution electrospray ionization mass spectrum, 1D and 2D nuclear magnetic resonance, as well as electronic circular dichroism. All 11 compounds were tested for their inhibitory activity against -glucosidase. Compound showed moderate inhibitory activity against -glucosidase with IC of 74.35 μM.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2018.1485661