A Helicobacter pylori-associated insulin resistance in asymptomatic sedentary young men does not correlate with inflammatory markers and urine levels of 8-iso-PGF 2 -α or 1,4-dihydroxynonane mercapturic acid

A potential contribution of H. pylori contamination to low-grade inflammation, oxidative stress (OS) and insulin resistance as well as correlations between these parameters in asymptomatic sedentary males was analysed. We enrolled 30 apparently healthy asymptomatic young subjects (18 H. pylori negat...

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Published inArchives of physiology and biochemistry Vol. 124; no. 3; pp. 275 - 285
Main Authors Cherkas, Andriy, Golota, Sergii, Guéraud, Françoise, Abrahamovych, Orest, Pichler, Christoph, Nersesyan, Armen, Krupak, Volodymyr, Bugiichyk, Vira, Yatskevych, Ostap, Pliatsko, Mykhaylo, Eckl, Peter, Knasmüller, Siegfried
Format Journal Article
LanguageEnglish
Published England 01.07.2018
Subjects
Adult
Asymptomatic Diseases
Biomarkers - metabolism
Dinoprost - analogs & derivatives
Dinoprost - urine
Helicobacter pylori - physiology
Humans
Inflammation - metabolism
Insulin Resistance
Male
Sedentary Behavior
Young Adult
Helicobacter pylori
sedentary lifestyle
inflammation
insulin resistance
oxidative stress
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Summary:A potential contribution of H. pylori contamination to low-grade inflammation, oxidative stress (OS) and insulin resistance as well as correlations between these parameters in asymptomatic sedentary males was analysed. We enrolled 30 apparently healthy asymptomatic young subjects (18 H. pylori negative and 12 positive) and measured whole blood glucose, glycated haemoglobin, insulin, C-peptide, cortisol, aldosterone, testosterone, thyroid stimulating hormone, C-reactive protein, interleukins 6 and 10, TNF-alpha and comet assay. As markers of OS, we used urine levels of iso-PGF -α and 1,4-dihydroxynonane mercapturic acid (DHN-MA). Twofold elevation of fasting insulin level and HOMA index in H. pylori-positive subjects (p < .05) was shown. Inflammatory parameters and monocyte DNA damage, urine levels of DHN-MA and iso-PGF2-α did not show significant differences between the groups. The early stage of H. pylori-triggered metabolic derangements in sedentary subjects include development of insulin resistance in H. pylori-positive subjects; however, there is no evidence of systemic inflammatory and OS-related changes.
ISSN:1381-3455
1744-4160
DOI:10.1080/13813455.2017.1396346