Effects of Low- or Moderate-dose Whole Body-X-ray Radiation on the Immune System of C57BL/6 Mice

• Published in: Clinical pediatric hematology-oncology Vol. 25; no. 1; pp. 50 - 55
• Main Authors: Ko, Yunmi, Jeong, Yeon Ho, Lee, Jun Ah
• Format: Journal Article
• Language: English
• Published: 대한소아혈액종양학회 30.04.2018
• Subjects: 소아과학
• ISSN: 2233-5250; 2233-5250
• DOI: 10.15264/cpho.2018.25.1.50

Background: Increase in the use of diagnostic imaging or occupational exposure to radiation have brought upon concerns on the safety and biological effects of low- or moderate-dose radiation. However, limited information is available on the effects of low or moderate dose radiation on human health.. Methods: Using C57BL/6 mice, we aimed to evaluate the biological effects of low- and moderate-dose radiation on the immune system. X-rays was chosen as a radiation source and we analyzed complete blood counts, various lymphocyte subsets and various cytokine levels after single fraction x-ray exposure (0.1 Gy, 1 Gy). Results: No significant changes in the immunologic parameter of C57BL/6 mice were observed after radiation, except LIX (a cytokine equivalent to human CXCL5), that showed higher level after 0.1 Gy radiation compared to the control. Conclusion: We observed that a single fraction of low or moderate dose of X-ray radiation does not cause significant changes in the immune system of C57BL/6 mice. Further studies are necessary to elucidate the mechanism underlying our results. KCI Citation Count: 0