The electrostatic confinement of aquated monocationic Gd( iii ) complex-molecules within the inner core of porous silica nanoparticles creates a highly efficient T 1 contrast agent for magnetic resonance imaging
Contrast-agent enhanced magnetic resonance imaging (MRI) has been under continuous investigation for the conspicuous imaging of lesions and the early-stage detection of tumors. To achieve the development of a T 1 -weighted contrast agent with a high relaxivity value, herein, porous silica nanopartic...
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Published in | Dalton transactions : an international journal of inorganic chemistry Vol. 51; no. 37; pp. 14138 - 14149 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
26.09.2022
|
Online Access | Get full text |
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Summary: | Contrast-agent enhanced magnetic resonance imaging (MRI) has been under continuous investigation for the conspicuous imaging of lesions and the early-stage detection of tumors. To achieve the development of a
T
1
-weighted contrast agent with a high relaxivity value, herein, porous silica nanoparticles that had internalized about 20 aquated cationic Gd(
iii
) complexes (1) of the hexadentate hydroxyethyl-appended picolinate-based ligand H
2
hbda were demonstrated. Complex 1 exhibited a longitudinal relaxivity value per mM Gd(
iii
) ions,
r
1
, of 9.05 mM
−1
s
−1
(pH 7.4, 37 °C, 1.41 T), which increased to 86.41 mM
−1
s
−1
because of the grafting of complex 1 in the inner core of porous silica nanospheres through electrostatic interactions between the anionic silica surface and the cationic complex 1 molecules. A further augmentation in the relaxivity value to 118.32 mM
−1
s
−1
was realized because of the interaction of the complex 1@SiO
2
NPs with serum albumin protein. The synthesized nanosystem was impervious to physiologically available anions (HPO
4
2−
and HCO
3
1−
) and also kinetically inert, as evidenced
via
a transmetallation experiment in the presence of Zn(
ii
) ions. The developed complex-incorporated nanomaterial was bio- and hemo-compatible. Cellular uptake measurements employing HeLa cells and the concentration-dependent enhancement in the brightness of
in vitro
phantom images, recorded under a clinical scanner at 1.5 T, demonstrated that the developed biocompatible 1@SiO
2
NP complex has promising diagnostic applications as a
T
1
-weighted MRI contrast agent. |
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ISSN: | 1477-9226 1477-9234 |
DOI: | 10.1039/D2DT02272A |