How to protect environment and employees against cytotoxic agents, the UZ Ghent experience

• Published in: Journal of oncology pharmacy practice Vol. 6; no. 4; pp. 146 - 152
• Main Authors: Vandenbroucke, J., Robays, H.
• Format: Journal Article
• Language: English
• Published: London Sage Publications Ltd 01.04.2000
• ISSN: 1078-1552; 1477-092X
• DOI: 10.1191/107815501701563424

Objective. Two different systems for the reconstitution and preparation of cytotoxic drug-containing infusion bags were compared in a contamination study using both wipe samples of the Biological Safety Cabinet (BSC) plus surroundings and urine analysis of technicians and pharmacists involved in the preparatory activities. The Classical System (open) uses Luer lock syringes and needles, and the PhaSeal® System (closed) uses special devices. Methods. Analyses were performed using gas chromatography in tandem with mass spectroscopy. Results. A significant difference has been found in the surface contamination rate, as well as the BSC's surroundings and in the number of persons, number of periods, and values of contaminated urine samples in favour of the closed PhaSeal® System. J Oncol Pharm Practice (2001) 6, 146-152.