2B.04: FACTORS RELATED TO THE LINK BETWEEN URIC ACID AND SYSTOLIC BLOOD PRESSURE IN YOUTHS

• Published in: Journal of hypertension Vol. 33 Suppl 1; p. e23
• Main Authors: Torro, M I, Alvarez, J, Aguilar, F, Redon, P, Lurbe, E
• Format: Journal Article
• Language: English
• Published: England 01.06.2015
• ISSN: 1473-5598
• DOI: 10.1097/01.hjh.0000467409.09656.9e

The present research was undertaken to analyze factors related to the link between uric acid (UA) and office blood pressure (BP) in normotensive, high-normal and untreated essential hypertensive youths. Six hundred and forty three Caucasians of both sexes (321 females), of European origin, predominantly obese, from 6 to 18 years of age (mean age 11.7 2.4) were included. The subjects were divided into 3 groups: normotensives 559 (87%; 92 non-obese), high-normal BP 58 (9%; 19 non-obese) or hypertensives 26 (4%; 5 non-obese) according to the ESH office BP criteria (Lurbe et al, J Hypertens 2009). Fasting blood was obtained and glucose, insulin, lipid profile, and UA were assessed. In relation to the general characteristics, there were no differences among groups regarding age, BMI, BMI-zscore, HDL and insulin. Uric acid increases across the BP range from normotensive to hypertensive groups. Controlling by age and sex, UA was significantly correlated with BMI (r = 0.180, p = 0.000), BMI Z-score (r = 0.175; p = 0.000), SBP (r = 0.20; p = 0.000), insulin (r = 0.23; p = 0.000), and HDL (r = -0.149; p = 0.000). In a multiple regression analysis office SBP, insulin, and HDL cholesterol were independent determinants of UA when age, sex, and BMI were included (r2 = 0.25). Office systolic BP was the main determinant of UA in a stepwise analysis. Even though UA was corrected by body size, UA/BMI ratio, systolic BP was the main determinant in boys (See figure).(Figure is included in full-text article.) : Uric acid is associated with BP, independently of metabolic factors in boys. The clinical implications require further investigation.