A Comprehensive Enumeration of the Human Proteostasis Network. 1. Components of Translation, Protein Folding, and Organelle-Specific Systems

The condition of having a healthy, functional proteome is known as protein homeostasis, or proteostasis. Establishing and maintaining proteostasis is the province of the proteostasis network, approximately 2,500 genes that regulate protein synthesis, folding, localization, and degradation. The prote...

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Published inbioRxiv
Main Authors The Proteostasis Consortium, Elsasser, Suzanne, Finley, Daniel, Mockler, Eric, Lima, Leandro, Finkbeiner, Steven, Gestwicki, Jason E, Stoeger, Thomas E, Cao, Kedi, Garza, Dan, Kelly, Jeffery W, Collier, Miranda, T Kelly Rainbolt, Taguwa, Shuhei, Chou, Ching-Chieh, Aviner, Ranen, Barbosa, Natalia, Moralez-Polanco, Fabian, Masto, Vincent B, Frydman, Judith, Elia, Lisa P, Morimoto, Richard I, Powers, Evan T
Format Paper
LanguageEnglish
Published Cold Spring Harbor Cold Spring Harbor Laboratory Press 02.09.2022
Subjects
Autophagy
Enumeration
Homeostasis
Localization
Organelles
Proteasomes
Protein biosynthesis
Protein folding
Protein structure
Protein synthesis
Proteins
Proteomes
Ubiquitin
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Summary:The condition of having a healthy, functional proteome is known as protein homeostasis, or proteostasis. Establishing and maintaining proteostasis is the province of the proteostasis network, approximately 2,500 genes that regulate protein synthesis, folding, localization, and degradation. The proteostasis network is a fundamental entity in biology with direct relevance to many diseases of protein conformation. However, it is not well defined or annotated, which hinders its functional characterization in health and disease. In this series of manuscripts, we aim to operationally define the human proteostasis network by providing a comprehensive, annotated list of its components. Here, we provide a curated list of 959 unique genes that comprise the protein synthesis machinery, chaperones, folding enzymes, systems for trafficking proteins into and out of organelles, and organelle-specific degradation systems. In subsequent manuscripts, we will delineate the human autophagy-lysosome pathway, the ubiquitin-proteasome system, and the proteostasis networks of model organisms. Competing Interest Statement The authors have declared no competing interest.
DOI:10.1101/2022.08.30.505920