Havanensin-type Limonoids from the Stem Bark of Chisocheton pentandrus (Meliaceae)

A new limonoid, belonging to the havanensin-type, called pentandricine E (1), alongside four other known types, i.e., trichilenone acetate (2), toonaciliatones C (3), 11α-acetoxyazadirone (4) and ceramicine I (5), were found in Chisocheton pentandrus stem bark. The structures of the isolated 1-5 wer...

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Bibliographic Details
Published inJournal of mathematical and fundamental sciences Vol. 54; no. 3; pp. 302 - 310
Main Authors Supratman, Unang, Runadi, Dudi, Purnama, Purnama, Salam, Supriatno, Nurlelasari, Nulelasari, Harneti, Desi, Mayanti, Tri, Maharani, Rani, Shiono, Yoshihito
Format Journal Article
LanguageEnglish
Published ITB Journal Publisher 15.05.2023
Subjects
Chisocheton pentandrus
havanensin-type
MCF-7
pentandricine E
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Summary:A new limonoid, belonging to the havanensin-type, called pentandricine E (1), alongside four other known types, i.e., trichilenone acetate (2), toonaciliatones C (3), 11α-acetoxyazadirone (4) and ceramicine I (5), were found in Chisocheton pentandrus stem bark. The structures of the isolated 1-5 were identified by NMR spectroscopy and HRTOFMS. Pentandricine E (1) displayed the highest cytotoxicity toward the MCF-7 breast cancer line with an IC50 value of 63.27 ± 0.21 mM.
ISSN:2337-5760
2338-5510
DOI:10.5614/j.math.fund.sci.2022.54.3.2