Presence of Plasmid-Mediated Quinolone Resistance in Klebsiella pneumoniae Isolates Possessing bla KPC in the United States

ABSTRACT The presence of plasmid-mediated quinolone resistance genes [i.e., qnrA , qnrB , qnrS , aac(6 ′ )-Ib-cr , and qepA ] was evaluated among 42 bla KPC -containing Klebsiella pneumoniae isolates collected in the eastern United States. One isolate carried the bla KPC-3 and qnrB19 genes on the sa...

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Published inAntimicrobial agents and chemotherapy Vol. 52; no. 7; pp. 2680 - 2682
Main Authors Endimiani, Andrea, Carias, Lenore L., Hujer, Andrea M., Bethel, Christopher R., Hujer, Kristine M., Perez, Federico, Hutton, Rebecca A., Fox, William R., Hall, Geraldine S., Jacobs, Michael R., Paterson, David L., Rice, Louis B., Jenkins, Stephen G., Tenover, Fred C., Bonomo, Robert A.
Format Journal Article
LanguageEnglish
Published 01.07.2008
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Summary:ABSTRACT The presence of plasmid-mediated quinolone resistance genes [i.e., qnrA , qnrB , qnrS , aac(6 ′ )-Ib-cr , and qepA ] was evaluated among 42 bla KPC -containing Klebsiella pneumoniae isolates collected in the eastern United States. One isolate carried the bla KPC-3 and qnrB19 genes on the same conjugative plasmid, whereas another carried the bla KPC-3 and qnrA1 genes on separate plasmids.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.00158-08