Adhesion Anisotropy Substrate with Janus Micropillar Arrays Guides Cell Polarized Migration and Division Cycle

Cell migration is a ubiquitous and important cell behaviour. Construction of an interface that can guide and induce cell migration is of significance for studying cell behaviour and carrying out the transplantation of biological materials. Herein, we prepare a micropillar array by precise modificati...

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Published inAngewandte Chemie Vol. 131; no. 13; pp. 4352 - 4356
Main Authors Liu, Sidi, Nie, Yifeng, Zhang, Qiang, Zhu, Yuting, Li, Xiang, Han, Dong
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 22.03.2019
Subjects
Adhesion
Anisotrope Adhäsion
Anisotropy
Arrays
Asymmetrische Modifizierungen
Bioinformatics
Bioinformatik
Biological materials
Cell adhesion & migration
Cell division
Cell migration
Chemistry
Functional groups
Gene expression
Janus-Mikrosäulen-Arrays
Melanoma
Substrates
Transplantation
Zellmigration und -teilung
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Summary:Cell migration is a ubiquitous and important cell behaviour. Construction of an interface that can guide and induce cell migration is of significance for studying cell behaviour and carrying out the transplantation of biological materials. Herein, we prepare a micropillar array by precise modification of two different functional groups on each micropillar unit to obtain a “Janus” structure with anisotropic cell‐adhesion properties. This anisotropic structure was capable of influencing the focal adhesion pathway of melanoma cells as shown by transcriptome sequencing and bioinformatics analysis. This the anisotropic substrate can considerably affect the migration ability of highly invasive melanoma cells. The anisotropic structure with Janus micropillar arrays could also affect the cell division cycle. The experiments showed that the anisotropic microstructures regulate cell migration and are thus of use in the research of cell migration without drug stimulation. Gesteuerte Migration: Ein anisotropes Substrat für die Zelladhäsion auf Basis eines Janus‐Mikrosäulen‐Arrays steuert die Zellmigration durch Regulation des zellulären Fokaladhäsionswegs. Es kann zudem den Zellteilungszyklus fördern und lässt sich zum Studium der Zellmigration ohne Wirkstoffstimulation nutzen.
Bibliography:These authors contributed equally to this work.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.201814579