Near‐Infrared Thermally Activated Delayed Fluorescence Nanoparticle: A Metal‐Free Photosensitizer for Two‐Photon‐Activated Photodynamic Therapy at the Cell and Small Animal Levels (Small 6/2022)

Photodynamic Therapy In article number 2106215, Menglin Li, Jinfeng Zhang, and co‐workers develop a metal‐free photosensitizer (PS) based on thermally activated delayed fluorescence (TADF) nanoparticles, which demonstrates intrinsic two‐photon‐excited (TPE) property, near‐infrared emissive fluoresce...

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Published inSmall (Weinheim an der Bergstrasse, Germany) Vol. 18; no. 6
Main Authors Fang, Fang, Yuan, Yi, Wan, Yingpeng, Li, Jing, Song, Yueyue, Chen, Wen‐Cheng, Zhao, Dongxu, Chi, Yun, Li, Menglin, Lee, Chun‐Sing, Zhang, Jinfeng
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 01.02.2022
Subjects
Fluorescence
metal‐free photosensitizers
Nanoparticles
Nanotechnology
near‐infrared emission
Photodynamic therapy
Photons
Singlet oxygen
thermally activated delayed fluorescence (TADF)
Translations
two‐photon activated photodynamic therapy
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Summary:Photodynamic Therapy In article number 2106215, Menglin Li, Jinfeng Zhang, and co‐workers develop a metal‐free photosensitizer (PS) based on thermally activated delayed fluorescence (TADF) nanoparticles, which demonstrates intrinsic two‐photon‐excited (TPE) property, near‐infrared emissive fluorescence, and singlet oxygen generation ability. Moreover, the TPE‐photodynamic therapy (PDT) performance and biosafety at the small animal level are investigated. This work provides a promising strategy to develop metal‐free PSs and advances the potential clinical translations of TADF‐based nanotherapeutics for high‐precision bio‐imaging and high‐performance PDT.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.202270025