Visible-Light Photoredox-Catalyzed Dicarbofunctionalization of Styrenes with Oxime Esters and CO 2 : Multicomponent Reactions toward Cyanocarboxylic Acids and γ-Keto Acids

A photoredox-catalyzed dicarbofunctionalization of styrenes with oxime esters and CO has been achieved. Notably, a series of four-, five-, or six-membered cyclic ketone oximes worked well to furnish a wide range of ε-, ζ-, and η-cyanocarboxylic acids in good yields. Furthermore, a series of γ-keto a...

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Bibliographic Details
Published inOrganic letters Vol. 23; no. 24; pp. 9654 - 9658
Main Authors Bai, Junxue, Li, Miao, Zhou, Cong, Sha, Yu, Cheng, Jiang, Sun, Jianwei, Sun, Song
Format Journal Article
LanguageEnglish
Published United States 17.12.2021
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Summary:A photoredox-catalyzed dicarbofunctionalization of styrenes with oxime esters and CO has been achieved. Notably, a series of four-, five-, or six-membered cyclic ketone oximes worked well to furnish a wide range of ε-, ζ-, and η-cyanocarboxylic acids in good yields. Furthermore, a series of γ-keto acids also could be obtained by employing acyclic ketone oxime esters as the carbonyl radical precursor. It provides convergent access to diverse biologically important cyanocarboxylic and γ-keto acids.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c03938