The possibility of using neuron-specific enolase as a biomarker in the acute period of stroke

The article presents a review of the literature on neuron-specific enolase (NSE) as a biomarker of stroke. It is shown that NSE does not allow differentiation of the ischemic and hemorrhagic process in stroke, but is suitable for determining the extent of brain tissue destruction both in the first h...

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Published inZhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Vol. 119; no. 8. Vyp. 2; p. 53
Main Authors Topuzova, M P, Alekseeva, T M, Panina, E B, Vavilova, T V, Kovzelev, P D, Portik, O A, Skoromets, A A
Format Journal Article
LanguageRussian
Published Russia (Federation) 2019
Subjects
Biomarkers - analysis
Brain
Brain Ischemia
Humans
Phosphopyruvate Hydratase - analysis
Stroke - diagnosis
prediction
stroke
stroke biomarkers
neuron-specific enolase (NSE)
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Summary:The article presents a review of the literature on neuron-specific enolase (NSE) as a biomarker of stroke. It is shown that NSE does not allow differentiation of the ischemic and hemorrhagic process in stroke, but is suitable for determining the extent of brain tissue destruction both in the first hours of stroke and in the dynamics. The HSE analysis can be useful for monitoring the course of the disease, control of the dynamics of the pathological process, including when the size of the lesion increases, for evaluating the effectiveness of therapy and as a prognostic biomarker.
ISSN:1997-7298
DOI:10.17116/jnevro201911908253