Heterotrimeric Gα 12/13 proteins in kidney injury and disease

Gα and Gα are ubiquitous members of the heterotrimeric guanine nucleotide-binding protein (G protein) family that play central and integrative roles in the regulation of signal transduction cascades within various cell types in the kidney. Gα /Gα proteins enable the kidney to adapt to an ever-changi...

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Bibliographic Details
Published inAmerican journal of physiology. Renal physiology Vol. 318; no. 3; pp. F660 - F672
Main Authors Tutunea-Fatan, Elena, Lee, Jasper C, Denker, Bradley M, Gunaratnam, Lakshman
Format Journal Article
LanguageEnglish
Published United States 01.03.2020
Subjects
acute kidney injury
Gα12/13 family
kidney pathology
signal transduction
kidney injury molecule-1
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Summary:Gα and Gα are ubiquitous members of the heterotrimeric guanine nucleotide-binding protein (G protein) family that play central and integrative roles in the regulation of signal transduction cascades within various cell types in the kidney. Gα /Gα proteins enable the kidney to adapt to an ever-changing environment by transducing stimuli from cell surface receptors and accessory proteins to effector systems. Therefore, perturbations in Gα /Gα levels or their activity can contribute to the pathogenesis of various renal diseases, including renal cancer. This review will highlight and discuss the complex and expanding roles of Gα /Gα proteins on distinct renal pathologies, with emphasis on more recently reported findings. Deciphering how the different Gα /Gα interaction networks participate in the onset and development of renal diseases may lead to the discovery of new therapeutic strategies.
ISSN:1931-857X
1522-1466
DOI:10.1152/ajprenal.00453.2019