ChemInform Abstract: Indolinol‐Catalyzed Asymmetric Michael Reaction of Aldehydes to Nitroalkenes in Brine

The asymmetric Michael reaction of nitroalkenes (I) with aldehydes (II) proceeds with good to high enantio‐ and diastereoselectivity, whilst the reaction of nitroalkene (VI) gives rise to a mixture of syn/anti‐diastereomers with 45:55 ratio.

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Bibliographic Details
Published inChemInform Vol. 47; no. 35; p. no
Main Authors Hu, Xin, Wei, Yi‐Fei, Wu, Nan, Jiang, Zhiguo, Liu, Can, Luo, Ren‐Shi
Format Journal Article
LanguageEnglish
Published Weinheim WILEY‐VCH Verlag 01.08.2016
Wiley Subscription Services, Inc
Subjects
addition reactions
diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism)
nitro compounds (benzene compounds)
organocatalysis
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Summary:The asymmetric Michael reaction of nitroalkenes (I) with aldehydes (II) proceeds with good to high enantio‐ and diastereoselectivity, whilst the reaction of nitroalkene (VI) gives rise to a mixture of syn/anti‐diastereomers with 45:55 ratio.
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201635023