Visible-Light Photoredox-Catalyzed Intermolecular α-Aminomethyl/Carboxylative Dearomatization of Indoles with CO 2 and α-Aminoalkyl Radical Precursors

Disclosed here is a visible-light photoredox-catalyzed intermolecular sequential α-aminomethyl/carboxylative dearomatization of indoles with CO and α-aminoalkyl radical precursors, affording a series of functionalized indoline-3-carboxylic acids and lactams in good yields with high regioselectivity....

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Bibliographic Details
Published inOrganic letters Vol. 26; no. 2; pp. 467 - 472
Main Authors Gao, Wanxu, Yang, Qi, Yang, Han, Yao, Yang, Bai, Junxue, Sun, Jianwei, Sun, Song
Format Journal Article
LanguageEnglish
Published United States 19.01.2024
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Summary:Disclosed here is a visible-light photoredox-catalyzed intermolecular sequential α-aminomethyl/carboxylative dearomatization of indoles with CO and α-aminoalkyl radical precursors, affording a series of functionalized indoline-3-carboxylic acids and lactams in good yields with high regioselectivity. This multicomponent reaction provides a green and facile method for the synthesis of diverse functionalized indolines by using CO as the carboxylic and carbonyl source.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.3c03755