Frontispiece: Universality of the Sodium Ion Binding Mechanism in Class A G‐Protein‐Coupled Receptors

Allosteric Modulators In their Communication on page 3048 ff., D. Shukla et al. determine the free energy barriers for Na+ ion binding to the allosteric site of 18 G‐protein‐coupled receptors using Markov state models.

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Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 57; no. 12
Main Authors Selvam, Balaji, Shamsi, Zahra, Shukla, Diwakar
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 12.03.2018
EditionInternational ed. in English
Subjects
allosteric modulators
Allosteric properties
Binding
Free energy
G-protein-coupled receptors
Markov chains
Modulators
molecular dynamics
Receptors
signal transduction
Sodium
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Summary:Allosteric Modulators In their Communication on page 3048 ff., D. Shukla et al. determine the free energy barriers for Na+ ion binding to the allosteric site of 18 G‐protein‐coupled receptors using Markov state models.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201881261