Potentiation of general anaesthetic activity of ketamine by memantine

• Published in: International journal of basic and clinical pharmacology Vol. 9; no. 1; p. 146
• Main Authors: Umamageswari, M. S., Vasanthan, K., Karthikeyan, T. M.
• Format: Journal Article
• Language: English
• Published: 01.01.2020
• ISSN: 2319-2003; 2279-0780
• DOI: 10.18203/2319-2003.ijbcp20195777

Background: The study was done with the objective to evaluate synergistic activity of ketamine induced general anesthesia by memantine in wistar albino rats.Methods: The wistar albino rats of either sex were divided into four groups of five animals. Group 1 received ketamine 40 mg/kg, group 2 received ketamine 80 mg/kg, group 3 received ketamine 40 mg/kg along with memantine 10 mg/kg and group 4 received 80 mg of ketamine along with memantine 10 mg/kg to evaluate the synergistic activity of ketamine induced general anesthesia by memantine. The sleep latency time and duration of sleep were measured in all the groups.Results: The sleep latency time of group 4 is significantly decreased (p<0.001) compared to all other groups. The duration of sleep of group 4 is significantly increased (p<0.001) compared to group 1 and group 3, but less than that of group 1.Conclusions: Memantine possess synergistic activity of ketamine induced general anaesthesia.