Drug-Induced Liver Injury in Tuberculosis: Mechanisms of Development and Diagnostic Methods

The review article discusses modern aspects of drug-induced liver injury (DILI) in patients with tuberculosis who are receiving etiotropic therapy. The main mechanisms of DILI, including toxic and idiosyncratic types, are described, as well as their pathogenetic, biochemical, and epidemiological dif...

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Published inJuvenis scientia Vol. 9; no. 1; pp. 24 - 42
Main Authors Sukhanov, D. S., Timofeev, E. V., Alekseeva, Yu. S., Azovtsev, D. Yu
Format Journal Article
LanguageEnglish
Published Scientia Publishing House 01.02.2023
Subjects
diagnosis
diagnostic criteria
drug hepatitis
drug-induced liver injury
etiotropic therapy
liver enzymes
toxic hepatitis
transaminases
tuberculosis
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Summary:The review article discusses modern aspects of drug-induced liver injury (DILI) in patients with tuberculosis who are receiving etiotropic therapy. The main mechanisms of DILI, including toxic and idiosyncratic types, are described, as well as their pathogenetic, biochemical, and epidemiological differences. DILI can manifest as various clinicomorphological forms of liver damage, such as steatosis and steatohepatitis, acute and chronic hepatitis, mitochondrial cytopathy, cholestasis, sclerosing cholangitis, vascular injury, and others. The main diagnostic method for DILI is the detection of liver enzymes - transaminases and alkaline phosphatase - based on the degree of elevation and their ratio, which identify two main types of liver injury - hepatocellular and cholestatic - as well as a mixed variant. The article provides a scoring assessment of liver damage in a patient receiving chemotherapy to classify it as drug-induced liver injury.
ISSN:2414-3782
2414-3790
DOI:10.32415/jscientia_2023_9_1_24-42