Identification of N-acetylglucosaminyltranferase-IV as a modifier of Epstein-Barr virus BZLF1 activity

Epstein-Barr virus is a prevalent human herpesvirus, with about 95% of the world's adult population positive for anti-EBV antigen antibodies. After the initial infection and production of new virus particles, the virus may enter a latent state within a subset of cells, and therefore can remain...

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Bibliographic Details
Published inOpen journal of genetics Vol. 3; no. 1; pp. 1 - 5
Main Author Adamson, Amy L.
Format Journal Article
LanguageEnglish
Published 01.03.2013
Subjects
Drosophila melanogaster
Epstein-Barr virus
Human herpesvirus
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Summary:Epstein-Barr virus is a prevalent human herpesvirus, with about 95% of the world's adult population positive for anti-EBV antigen antibodies. After the initial infection and production of new virus particles, the virus may enter a latent state within a subset of cells, and therefore can remain within the host indefinitely. Epstein-Barr virus contributes to a variety of diseases, including many types of cancers. We have created a model system in Drosophila melanogaster to study the effect of expression of the Epstein-Barr virus protein BZLF1, and to identify cellular proteins that mediate BZLF1 activity. Here we present the results of a genetic screen that determined that the Drosophila melanogaster CG9384 gene (an N-acetylglucosaminyl-transferase) is a significant modulator of BZLF1 activity and EBV early lytic replication.
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ISSN:2162-4453
2162-4461
DOI:10.4236/ojgen.2013.31001