Altered levels of inhibitory cytokines in patients with thalassemia major and gingival inflammation

• Published in: Brazilian dental science Vol. 22; no. 3; pp. 349 - 357
• Main Authors: Akcalı, Aliye, Kahraman Çeneli, Selda, Meriç, Pınar, Nalbantsoy, Ayse, Ozçaka, Özgün, Buduneli, Nurcan
• Format: Journal Article
• Language: English
• Published: 30.07.2019
• ISSN: 2178-6011; 2178-6011
• DOI: 10.14295/bds.2019.v22i3.1708

Objective: To evaluate local and systemic levels of interleukin-10 (IL-10), IL-33, and tumor necrosis factor alpha (TNF-?) in Thalassemia major (TM) in the presence of gingival inflammation. Material and Methods: 58 patients (TM, n=29 and systemically healthy controls, n=29) were included to the study. IL-10, IL-33, and TNF-? levels were evaluated in gingival crevicular fluid (GCF), saliva and serum. Clinical periodontal measurements were recorded. Results: GCF IL-33 total amounts in TM and gingivitis group were elevated compared to systemically and periodontally healthy group (p=0.01). GCF IL-10, IL-33 and TNF-? concentrations were higher in TM and periodontally healthy group than the systemically healthy and gingivitis group (p=0.02, p=0.008, p=0.003). Serum IL-10 levels were elevated in TM and gingivitis compared to the systemically healthy and gingivitis (p=0.0009) and systemically and periodontally healthy (p=0.0007) groups. Serum IL-10 and TNF-? levels in TM and periodontally healthy group were higher than systemically and periodontally healthy group (p=0.01 and p=0.02). Conclusion: TM may potentially alter circulating levels of IL-33 and IL-10 and therefore, may affect the degree of periodontal inflammation locally or vice versa. Yet, the underlying mechanism linking the hematologic condition is not clear and deserves further investigation. KeywordsGingivitis; Thalassemia major; Interleukin-10; Interleukin-33; Tumor Necrosis Factor-alpha.