Altered regional homogeneity in post-traumatic stress disorder： a resting-state functional magnetic resonance imaging study

Objective Little is known about the brain systems that contribute to vulnerability to post-traumatic stress disorder （PTSD）. Comparison of the resting-state patterns of intrinsic functional synchronization, as measured by functional magnetic resonance imaging （fMRI）, between groups with and without...

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Published inNeuroscience bulletin Vol. 28; no. 5; pp. 541 - 549
Main Authors Yin, Yan, Jin, Changfeng, Eyler, Lisa T, Jin, Hua, Hu, Xiaolei, Duan, Lian, Zheng, Huirong, Feng, Bo, Huang, Xuanyin, Shan, Baoci, Gong, Qiyong, Li, Lingjiang
Format Journal Article
LanguageEnglish
Published Singapore 01.10.2012
Subjects
Adolescent
Adult
Brain - metabolism
Earthquakes
Female
fMRI
Humans
Magnetic Resonance Imaging - methods
Male
Middle Aged
Rest - physiology
Rest - psychology
Stress Disorders, Post-Traumatic - diagnosis
Stress Disorders, Post-Traumatic - metabolism
Stress Disorders, Post-Traumatic - psychology
Young Adult
创伤性
功能磁共振成像
同质性
应激
神经机制
脑神经系统
静息态
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Summary:Objective Little is known about the brain systems that contribute to vulnerability to post-traumatic stress disorder （PTSD）. Comparison of the resting-state patterns of intrinsic functional synchronization, as measured by functional magnetic resonance imaging （fMRI）, between groups with and without PTSD following a traumatic event can help identify the neural mechanisms of the disorder and targets for intervention. Methods Fifty-four PTSD patients and 72 matched traumatized subjects who experienced the 2008 Sichuan earthquake were imaged with blood oxygen level-dependent （BOLD） fMRI and analyzed using the measure of regional homogeneity （ReHo） during the resting state. Results PTSD patients presented enhanced ReHo in the left inferior parietal lobule and right superior frontal gyrus, and reduced ReHo in the right middle temporal gyrus and lingual gyrus, relative to traumatized individuals without PTSD. Conclusion Our findings showed that abnormal brain activity exists under resting conditions in PTSD patients who had been exposed to a major earthquake. Alterations in the local functional connectivity of cortical regions are likely to contribute to the neural mechanisms underlying PTSD.
Bibliography:functional magnetic resonance imaging; post-traumatic stress disorder; regional homogeneity; resting-state
Objective Little is known about the brain systems that contribute to vulnerability to post-traumatic stress disorder （PTSD）. Comparison of the resting-state patterns of intrinsic functional synchronization, as measured by functional magnetic resonance imaging （fMRI）, between groups with and without PTSD following a traumatic event can help identify the neural mechanisms of the disorder and targets for intervention. Methods Fifty-four PTSD patients and 72 matched traumatized subjects who experienced the 2008 Sichuan earthquake were imaged with blood oxygen level-dependent （BOLD） fMRI and analyzed using the measure of regional homogeneity （ReHo） during the resting state. Results PTSD patients presented enhanced ReHo in the left inferior parietal lobule and right superior frontal gyrus, and reduced ReHo in the right middle temporal gyrus and lingual gyrus, relative to traumatized individuals without PTSD. Conclusion Our findings showed that abnormal brain activity exists under resting conditions in PTSD patients who had been exposed to a major earthquake. Alterations in the local functional connectivity of cortical regions are likely to contribute to the neural mechanisms underlying PTSD.
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Yan Yin , Changfeng Jin , Lisa T. Eyler , Hua Jin , Xiaolei Hu , Lian Duan , Huirong Zheng , Bo Feng , Xuanyin Huang , Baoci Shan , Qiyong Gong , Lingjiang Li （ 1. Mental Health Institute, The Second Xiangya Hospital of Central South University, Changsha 410011, China ;2 .Shenyang Gongan Hospital, Shenyang 110003, China; 3. Chinese University of Hong Kong, Hong Kong, China ;4 .Department of Psychiatry, University of California–San Diego School of Medicine, San Diego, California, USA; 5. VA San Diego Mental Illness Research Education and Clinical Center, San Diego, California, USA; 6 .VA San Diego Healthcare System, San Diego, California, USA; 7. China University of Mining and Technology, Xuzhou 221116, China; 8. Guangdong Mental Health Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510120, China; 9. Mianzhu Psychiatric Hospital, Deyang 618200, China ;10 .Mental Health Center of Sichuan Province, Mianyang 621000, China; 11. Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China ;12 .Huaxi MR Research Center, Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, China）
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1673-7067
1995-8218
1995-8218
DOI:10.1007/s12264-012-1261-3