Pathological and protective effects of tumor necrosis factor-alpha in multiple sclerosis

• Published in: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Vol. 119; no. 10. Vyp. 2; p. 14
• Main Authors: Smagina, I V, Elchaninova, S A, Palashchenko, A S, Galaktionova, L P
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2019
• Subjects: Central Nervous System - immunology; Central Nervous System - metabolism; Humans; Multiple Sclerosis - immunology; Multiple Sclerosis - metabolism; Multiple Sclerosis - pathology; Multiple Sclerosis - prevention & control; Protective Factors; Tumor Necrosis Factor-alpha - antagonists & inhibitors; Tumor Necrosis Factor-alpha - immunology; Tumor Necrosis Factor-alpha - metabolism; tumor necrosis factor-alpha; tumor necrosis factor-alpha receptors; multiple sclerosis; central nervous system
• ISSN: 1997-7298
• DOI: 10.17116/jnevro20191191014

The immunomodulatory cytokine tumor necrosis factor-alpha (TNF-α) is involved in the regulation of both physiological and pathological processes in the central nervous system (CNS). The effects of TNF-α on CNS reported in clinical trials and experimental studies, evidence of involvement of this cytokine in the pathogenesis of multiple sclerosis are analyzed. Possible causes of failures of non-selective pharmacological inhibition of TNF-α effects in MS are considered in view of current concepts on mechanisms of TNF-α action.