Topical drug administration to the inner ear. Modern state of the problem and development perspectives

The work assessed modern methods of drug delivery through biological barriers to the lesion, in particular, through the most studied - skin. The main advantages and disadvantages of the existing methods for the topical administration of drugs into the inner ear - intra-imperial and intra-labyrinth d...

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Bibliographic Details
Published inVestnik otorinolaringologii Vol. 84; no. 5; p. 6
Main Authors Kryukov, A I, Kunelskaya, N L, Shershunova, E A, Rebrov, I E, Yamshchikov, V A, Garov, E V, Tsarapkin, G Yu, Mishchenko, V V
Format Journal Article
LanguageEnglish
Russian
Published Russia (Federation) 2019
Subjects
Administration, Topical
Anti-Bacterial Agents
Drug Delivery Systems
Ear, Inner
phonoelectrophoresis
Meniere’s disease
translabirint drug delivery
neurosensory hearing loss
electroporation
inner ear
cochleovestibular disorders
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Summary:The work assessed modern methods of drug delivery through biological barriers to the lesion, in particular, through the most studied - skin. The main advantages and disadvantages of the existing methods for the topical administration of drugs into the inner ear - intra-imperial and intra-labyrinth delivery are analyzed. A brief review of medicinal substances for topical administration to the inner ear, both widely used (for example, aminoglycosides, steroid drugs) and undergoing clinical trials, is given. An assessment is made of the prospects for the use of transmembrane drug delivery to the inner ear using an electric field, which has a combined electro-creative and iontophoretic effect.
ISSN:0042-4668
DOI:10.17116/otorino2019840516