Stimuli Response of Eu 3+ -Based Metallo-Supramolecular Polymers toward Pharmaceutical Amines

Metallo-supramolecular polymers offer a highly controllable platform for sensing. Their modular characteristics obtained by the ability of varying both building blocks, the metal ion and the organic ligand, provide tunability of their optical and chemical properties. Specifically, polymers based on...

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Bibliographic Details
Published inACS sensors Vol. 8; no. 4; pp. 1481 - 1488
Main Authors Ben-Shahar, Yuval, Shamai Yamin, Tamar, Marx, Sharon, Karton-Lifshin, Naama, Marciano, Daniele
Format Journal Article
LanguageEnglish
Published United States 28.04.2023
Subjects
Amines
Europium - chemistry
Lanthanoid Series Elements
Pharmaceutical Preparations
Polymers - chemistry
polymer dissociation
pharmaceutical amine sensor
metallo-supramolecular polymers (MSPs)
lanthanide luminescence
europium
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Summary:Metallo-supramolecular polymers offer a highly controllable platform for sensing. Their modular characteristics obtained by the ability of varying both building blocks, the metal ion and the organic ligand, provide tunability of their optical and chemical properties. Specifically, polymers based on lanthanide ions and conjugated aromatic ligands exhibit enhanced luminescence properties that can be altered by external stimulation. Herein, using europium-based polymers, we demonstrate the ability to detect different pharmaceutical amines, including in complex biological media, based on their luminescence quenching efficiency as a result of their polymer dissociation capacity. A combination of absorption, luminescence, and NMR measurements reveals combined static and dynamic quenching mechanisms that enable selective sensing of strong basic amines with high p values.
ISSN:2379-3694
2379-3694
DOI:10.1021/acssensors.2c02491