Effect of dietary plants on the production of immunoglobulins A in healthy Wistar rats

• Published in: Semina. Ciências biológicas e da saúde Vol. 43; no. 1; pp. 119 - 128
• Main Authors: Ruzon-Camargo, Flávia Imanishi, Fernandes, Eduardo Vignoto, Bocchi, Mayara, Oliveira, David Michel de, Venancio, Emerson José, Castro Gómez, Raul Jorge Hernan
• Format: Journal Article
• Language: English
• Published: Universidade Estadual de Londrina 01.02.2022
• Subjects: abelmoschus; antibodies; cinnamomum; curcuma; medicinal plants
• ISSN: 1676-5435; 1679-0367
• DOI: 10.5433/1679-0367.2022v43n1p119

Introduction: some plants such as turmeric, cinnamon, and okra are known to have therapeutic functions such as antioxidant and anti-inflammatory activity. Furthermore, an immunomodulatory role has been observed in the production of antibodies, in particular immunoglobulin A (IgA), which mediates a variety of protective functions for the organism. Objective: the aim of the present study was to investigate the effect of dietary plants on the production of IgA in healthy Wistar rats. Methods: thus, 48 male Wistar rats of 90 days of age were allocated to four groups. The animals were treated for 14 days with dried turmeric, cinnamon, or okra (50, 50, 12.5 mg/day, respectively) in phosphate buffered saline, or with only phosphate buffered saline by gavage. The animals received water and feed ad libitum. Body mass and relative weight ofperitoneal fat, adrenal gland, kidney, spleen, liver and thymus, biochemical parameters, and IgA levels were analyzed.Results: no significant changes were observed in the body mass, relative weight of organs and tissues, and biochemical parameters. An increase in serum IgA levels was observed in animals treated with turmeric or cinnamon.Conclusion: we conclude that the treatment with turmeric and cinnamon increased IgA production. Therefore, our study supports the idea that dietary supplementation with these plants may improve humoral immunity.